CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling

CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling

Abstract Background CD274 (programmed death ligand 1, also known as B7H1) is expressed in both solid tumors and hematologic malignancies and is of critical importance for the escape of tumor cells from immune surveillance by inhibiting T cell function via its receptor, programmed death 1 (PD-1). Inc...

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Bibliographic Details
Main Authors: Xia Fang, Chiqi Chen, Fangzhen Xia, Zhuo Yu, Yaping Zhang, Feifei Zhang, Hao Gu, Jiangbo Wan, Xiaocui Zhang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang, Li Xie, Junke Zheng
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Hematology & Oncology
Subjects:
Programmed death ligand-1/CD274
Leukemia-initiating cells
JNK
Cyclin D2
Cell cycle entry
Online Access:http://link.springer.com/article/10.1186/s13045-016-0350-6

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http://link.springer.com/article/10.1186/s13045-016-0350-6

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