Investigation of Non-Enzymatic Glycosylation of Human Serum Albumin Using Ion Trap-Time of Flight Mass Spectrometry

Investigation of Non-Enzymatic Glycosylation of Human Serum Albumin Using Ion Trap-Time of Flight Mass Spectrometry

Non-enzymatic glycosylation or glycation involves covalent attachment of reducing sugar residues to proteins without enzyme participation. Glycation of glucose to human serum albumin in vivo is related to diabetes and many other diseases. We present an approach using liquid chromatography coupled to...

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Bibliographic Details
Main Authors: Lianli Chi, Zhe Wang, Chengcai Huang, Xue Bai, Zhangjie Wang
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Molecules
Subjects:
glycation
human serum albumin
ion trap-time of flight
mass spectrometry
peptide fingerprinting
diabetes
incorporation ratio
Online Access:http://www.mdpi.com/1420-3049/17/8/8782

Internet

http://www.mdpi.com/1420-3049/17/8/8782

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