Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of Down syndrome

Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of Down syndrome

Down syndrome (DS) individuals present increased risk for Alzheimer disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn...

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Bibliographic Details
Main Authors: Silvina eCatuara-Solarz, Jose eEspinosa-Carrasco, Ionas eErb, Klaus eLangohr, Cedric eNotredame, Juan Ramón eGonzález, Mara eDierssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Aging
Down Syndrome
Principal Component Analysis
Morris water maze
(-)epigallocatechin-3-gallate
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00330/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00330/full

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