Chronic treatment with agents that stabilize cytosolic IκB-α enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch

Chronic treatment with agents that stabilize cytosolic IκB-α enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch

The potential pathogenic role of increased NFκB signaling in passively stretched dystrophic skeletal muscle was examined by treating adult mdx mice with an agent that stabilized cytosolic IκB-α (pyrollidine dithiocarbamate, PDTC)and examining the effects of this treatment on the chronically stretche...

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Bibliographic Details
Main Authors: C. George Carlson, Abbas Samadi, Ashley Siegel
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Duchenne muscular dystrophy
mdx Mouse
Dystrophinopathies
NFκB
IκB-α
Pyrollidine dithiocarbamate
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001415

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http://www.sciencedirect.com/science/article/pii/S0969996105001415

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