Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation

Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation

Although various advancements in radical surgery and neoadjuvant chemotherapy have been developed in treating osteosarcoma (OS), their clinical prognosis remains poor. A synthetic chemical compound, 3-hydroxylflavone, that is reported to regulate ROS production is known to inhibit human bone osteosa...

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Bibliographic Details
Main Authors: Chien-Yao Fu, Ing-Shiow Lay, Marthandam Asokan Shibu, Yan-Shen Tseng, Wei-Wen Kuo, Jaw-Ji Yang, Tso-Fu Wang, B. Mahalakshmi Bharath, Yu-Lan Yeh, Chih-Yang Huang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
osteosarcoma
3-Hydroxy-2-phenylchromone
ZAKβ
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/9/3366

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https://www.mdpi.com/1422-0067/21/9/3366

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