ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration

ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration

Swiss Cheese (SWS) is the Drosophila orthologue of Neuropathy Target Esterase (NTE), a phospholipase that when mutated has been shown to cause a spectrum of disorders in humans that range from intellectual disabilities to ataxia. Loss of SWS in Drosophila also causes locomotion deficits, age-depende...

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Bibliographic Details
Main Authors: Elizabeth R. Sunderhaus, Alexander D. Law, Doris Kretzschmar
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Unfolded protein response
Patatin-like phospholipase domain-containing protein 6
Sarco/endoplasmic reticulum Ca2+ ATPase
Lipid homeostasis
Spastic paraplegia/ataxia
Organophosphate-induced delayed neuropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303449

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http://www.sciencedirect.com/science/article/pii/S0969996118303449

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