Targeting Mitochondrial Ion Channels to Fight Cancer

• Main Authors: Magdalena Bachmann, Roberto Costa, Roberta Peruzzo, Elena Prosdocimi, Vanessa Checchetto, Luigi Leanza
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: International Journal of Molecular Sciences
• Subjects: ion channels; mitochondria; cancer cells
• Online Access: http://www.mdpi.com/1422-0067/19/7/2060

In recent years, several experimental evidences have underlined a new role of ion channels in cancer development and progression. In particular, mitochondrial ion channels are arising as new oncological targets, since it has been proved that most of them show an altered expression during tumor development and the pharmacological targeting of some of them have been demonstrated to be able to modulate cancer growth and progression, both in vitro as well as in vivo in pre-clinical mouse models. In this scenario, pharmacology of mitochondrial ion channels would be in the near future a new frontier for the treatment of tumors. In this review, we discuss the new advances in the field, by focusing our attention on the improvements in new drug developments to target mitochondrial ion channels.