Interaction Between ITM2B and GLUT9 Links Urate Transport to Neurodegenerative Disorders

Interaction Between ITM2B and GLUT9 Links Urate Transport to Neurodegenerative Disorders

Hyperuricemia plays a critical causative role in gout. In contrast, hyperuricemia has a protective effect in neurodegenerative disorders, including Alzheimer’s Disease. Genetic variation in the SLC2A9 gene, encoding the urate transporter GLUT9, exerts the largest single-gene effect on serum uric aci...

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Bibliographic Details
Main Authors: Asim K. Mandal, David B. Mount
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
integral membrane protein 2B (ITM2B)
SLC2A9 gene
urate transporter GLUT9
neurodegenerative disorders
Danish dementia
retinal dystrophy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01323/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.01323/full

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