Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles

Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles

Phosphodiesterase 7 (PDE7) is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP), an important cellular messenger. PDE7’s role in neurotransmission, expression profile in the brain and the druggability of other phosphodiesterases have motivated the search for potent i...

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Bibliographic Details
Main Authors: Vanesa Nozal, Elisa Rojas-Prats, Inés Maestro, Carmen Gil, Daniel I. Perez, Ana Martinez
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
nanoparticle
controlled release
brain penetration
phosphodiesterase 7 inhibitor
PLGA
nanoprecipitation
Online Access:https://www.mdpi.com/1422-0067/22/6/3206

Internet

https://www.mdpi.com/1422-0067/22/6/3206

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