Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age.

Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age.

Accumulation of reactive oxygen species (ROS) is an important pathogenic mechanism underling the loss of bone mass and strength with aging and other conditions leading to osteoporosis. The transcription factor erythroid 2-related factor2 (Nrf2) plays a central role in activating the cellular respons...

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Bibliographic Details
Main Authors: Gretel Gisela Pellegrini, Meloney Cregor, Kevin McAndrews, Cynthya Carolina Morales, Linda Doyle McCabe, George P McCabe, Munro Peacock, David Burr, Connie Weaver, Teresita Bellido
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5289572?pdf=render

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http://europepmc.org/articles/PMC5289572?pdf=render

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