Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands

Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands

Neurotensin subtype 1 receptors (NTS1R) represent attractive molecular targets for directing radiolabeled neurotensin (NT) analogs to tumor lesions for diagnostic and therapeutic purposes. This approach has been largely undermined by the rapid in vivo degradation of linear NT-based radioligands. Her...

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Bibliographic Details
Main Authors: Panagiotis Kanellopoulos, Aikaterini Kaloudi, Marion de Jong, Eric P. Krenning, Berthold A. Nock, Theodosia Maina
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
neurotensin
neurotensin subtype 1 receptor
<sup>99m</sup>Tc-radiotracer
tumor targeting
protease-inhibition
neprilysin-inhibitor
Online Access:https://www.mdpi.com/1999-4923/12/6/528

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https://www.mdpi.com/1999-4923/12/6/528

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