Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease

Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease

Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary cerebral small vessel diseases and is caused by mutations in NOTCH3. Our group has previously reported incorporation of NOTCH3 extracellular dom...

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Bibliographic Details
Main Authors: Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N. Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Raj N. Kalaria, Nobuya Inagaki, Ryosuke Takahashi, Mariko Harada-Shiba, Masafumi Ihara, Haruhisa Inoue
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Brain
Subjects:
CADASIL
Notch3
Mural cell
PDGFRβ
Induced pluripotent stem cell
Differentiation
Online Access:http://link.springer.com/article/10.1186/s13041-020-00573-w

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http://link.springer.com/article/10.1186/s13041-020-00573-w

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