Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [<sup>177</sup>Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model

Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [<sup>177</sup>Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model

1C1m-Fc, an anti-tumor endothelial marker 1 (TEM-1) scFv-Fc fusion protein antibody, was previously successfully radiolabeled with <sup>177</sup>Lu. TEM-1 specific tumor uptake was observed together with a non-saturation dependent liver uptake that could be related to the number of dodec...

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Bibliographic Details
Main Authors: Judith Anna Delage, Alain Faivre-Chauvet, Jacques Barbet, Julie Katrin Fierle, Niklaus Schaefer, George Coukos, David Viertl, Steven Mark Dunn, Silvano Gnesin, John O. Prior
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
TEM-1
fusion protein antibody
DOTA conjugation
<sup>177</sup>Lu radiolabeling
biodistribution
tumor/liver ratio
Online Access:https://www.mdpi.com/1999-4923/13/1/96

Internet

https://www.mdpi.com/1999-4923/13/1/96

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