Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

Clinical observations indicate that activation of the TNF-α system may contribute to the development of inflammation-associated depression. Here, we tested the hypothesis that systemic upregulation of TNF-α induces neuroinflammation and behavioral changes relevant to depression. We report that a sin...

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Bibliographic Details
Main Authors: Steven Biesmans, Jan A. Bouwknecht, Luc Ver Donck, Xavier Langlois, Paul D. Acton, Patrick De Haes, Nima Davoodi, Theo F. Meert, Niels Hellings, Rony Nuydens
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/716920

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http://dx.doi.org/10.1155/2015/716920

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