Synergistic Effects of Erzhi Pill Combined With Methotrexate on Osteoblasts Mediated via the Wnt1/LRP5/β-Catenin Signaling Pathway in Collagen-Induced Arthritis Rats

Synergistic Effects of Erzhi Pill Combined With Methotrexate on Osteoblasts Mediated via the Wnt1/LRP5/β-Catenin Signaling Pathway in Collagen-Induced Arthritis Rats

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by chronic synovitis, bone erosion, and bone loss. Erzhi Pill (EZP), a classic Chinese patent medicine, is often used to treat osteoporosis and shows a capacity for bone metabolism regulation. Methotrexate (MTX), an ess...

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Bibliographic Details
Main Authors: Xiaoya Li, Xiangcheng Lu, Danping Fan, Li Li, Cheng Lu, Yong Tan, Ya Xia, Hongyan Zhao, Miaoxuan Fan, Cheng Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
Erzhi Pill
Methotrexate
Wnt/β-catenin signaling pathway
Osteoblasts
synergistic effects
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00228/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00228/full

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