ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

Lymphocytic leukaemia cells are characterized by high respiratory rates. Here, the authors report that the oxysterol-binding protein ORPL4 sustains mitochondrial respiration in T-cell acute lymphoblastic leukaemia cells by regulating Ca2+release from the endoplasmic reticulum.

Bibliographic Details
Main Authors: Wenbin Zhong, Qing Yi, Bing Xu, Shiqian Li, Tong Wang, Fupei Liu, Biying Zhu, Peter R. Hoffmann, Guangju Ji, Pingsheng Lei, Guoping Li, Jiwei Li, Jian Li, Vesa M. Olkkonen, Daoguang Yan
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12702

Internet

https://doi.org/10.1038/ncomms12702

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