SOS1 promotes epithelial-mesenchymal transition of Epithelial Ovarian Cancer(EOC) cells through AKT independent NF-κB signaling pathway

SOS1 promotes epithelial-mesenchymal transition of Epithelial Ovarian Cancer(EOC) cells through AKT independent NF-κB signaling pathway

We aimed to explore the role and mechanism of SOS1 (Son of sevenless homolog 1) in malignant behaviors of epithelial ovarian cancer (EOC) cells Hey with high metastatic potential. Firstly, compared with Hey-WT (wild type) and Hey-NT (none targeted) cells, Hey-SOS1i cells showed decreased polarities,...

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Bibliographic Details
Main Authors: Min Cheng, Xiaolin Ye, Jiemin Dai, Feiji Sun
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Translational Oncology
Subjects:
SOS1
Ovarian cancer
Epithelial-mesenchymal transition
NF-κB signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001522

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http://www.sciencedirect.com/science/article/pii/S1936523321001522

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