A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells.

BACKGROUND:The pathologies of numerous retinal degenerative diseases can be attributed to a multitude of genetic factors, and individualized treatment options for afflicted patients are limited and cost-inefficient. In light of the shared neurodegenerative phenotype among these disorders, a safe and...

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Bibliographic Details
Main Authors: Ryan R Klimczak, James T Koerber, Deniz Dalkara, John G Flannery, David V Schaffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2758586?pdf=render