Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity

Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity

The transition metal ion cadmium (Cd2+) is a significant environmental contaminant. With a biological half-life of ~20 years, Cd2+ accumulates in the kidney cortex, where it particularly damages proximal tubule (PT) cells and can result in renal fibrosis, failure, or cancer. Because death represents...

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Bibliographic Details
Main Authors:	Frank Thévenod, Wing-Kee Lee
Format:	Article
Language:	English
Published:	MDPI AG 2015-04-01
Series:	Toxics
Subjects:	unfolded protein response transition metal cadmium apoptosis autophagosome acute kidney injury malignant transformation tunicamycin rapamycin mTORC
Online Access:	http://www.mdpi.com/2305-6304/3/2/130

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