Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A <sup>13</sup>C-Labeled Cerebral Microdialysis Study

Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A <sup>13</sup>C-Labeled Cerebral Microdialysis Study

Mitochondrial dysfunction after transient cerebral ischemia can be monitored by cerebral microdialysis (CMD) using changes in the lactate and pyruvate concentrations and ratio. Other metabolites associated with mitochondrial (dys)function are, e.g., tricyclic acid (TCA) and purine metabolites. Ethyl...

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Bibliographic Details
Main Authors: Kevin H. Nygaard, Jesper F. Havelund, Troels H. Nielsen, Carl-Henrik Nordström, Nils. J. Færgeman, Frantz R. Poulsen, Jan Bert Gramsbergen, Axel Forsse
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Metabolites
Subjects:
cerebral metabolism
labeled succinate
liquid chromatography—mass spectrometry
mitochondrial dysfunction
transient ischemia
Online Access:https://www.mdpi.com/2218-1989/10/7/287

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https://www.mdpi.com/2218-1989/10/7/287

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