Water-Soluble Coenzyme Q10 Inhibits Nuclear Translocation of Apoptosis Inducing Factor and Cell Death Caused by Mitochondrial Complex I Inhibition

Water-Soluble Coenzyme Q10 Inhibits Nuclear Translocation of Apoptosis Inducing Factor and Cell Death Caused by Mitochondrial Complex I Inhibition

The objectives of the study were to explore the mechanism of rotenone-induced cell damage and to examine the protective effects of water-soluble Coenzyme Q10 (CoQ10) on the toxic effects of rotenone. Murine hippocampal HT22 cells were cultured with mitochondrial complex I inhibitor rotenone. Water-s...

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Bibliographic Details
Main Authors: Haining Li, Guisheng Chen, Wanrui Ma, Ping-An Andy Li
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
apoptosis-inducing factor
Coenzyme Q10
mitochondrion
neuron
reactive oxygen species
mitochondrial membrane potential
rotenone
superoxide
ubiqunone
water-soluble Coenzyme Q10
Online Access:http://www.mdpi.com/1422-0067/15/8/13388

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http://www.mdpi.com/1422-0067/15/8/13388

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