Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver disease. Mechanisms that underlie this progression remain poorly understood, partly due to lack of good animal models that resemble human NASH. We...

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Bibliographic Details
Main Authors: Savitha Subramanian, Leela Goodspeed, Shari Wang, Jinkyu Kim, Lixia Zeng, George N. Ioannou, W. Geoffrey Haigh, Matthew M. Yeh, Kris V. Kowdley, Kevin D. O'Brien, Subramaniam Pennathur, Alan Chait
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Journal of Lipid Research
Subjects:
fatty liver
metabolic syndrome
oxysterols
apoptosis
oxidative stress
low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408545

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http://www.sciencedirect.com/science/article/pii/S0022227520408545

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