Efflux pump blockers in Gram-negative bacteria:The new generation of hydantoin based-modulators to improve antibiotic activity

Efflux pump blockers in Gram-negative bacteria:The new generation of hydantoin based-modulators to improve antibiotic activity

Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of new active antibiotic agents. Among effective mechanisms that contribute to the spread of MDR Gram-negative bacteria are drug efflux pumps that expel clinically important antibiotic classes out of the cell. Drug...

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Bibliographic Details
Main Authors: Ewa eOtrębska-Machaj, Jacqueline eChevalier, Jadwiga eHandzlik, Ewa eSzymańska, Jakub eSchabikowski, Gérard eBoyer, Jean-Michel eBolla, Katarzyna eKieć-Kononowicz, Jean-Marie ePAGES, Sandrine eAlibert
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Microbiology
Subjects:
Hydantoins
antibiotics
Multidrug resistance efflux pumps
AcrAB pump
Efflux pump blocker
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00622/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00622/full

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