Thromboxane A2 receptor stimulation enhances microglial interleukin-1β and NO biosynthesis mediated by the activation of ERK pathway

Thromboxane A2 receptor stimulation enhances microglial interleukin-1β and NO biosynthesis mediated by the activation of ERK pathway

AbstractBackground and Purpose: Thromboxane A2 (TXA2) receptors (TP) interact with the ligand TXA2 to induce platelet aggregation and regulate hemostasis. Recently TP-mediated signaling has been suggested to function in multiple cell types in the brain. In this report, we aim to study the expression...

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Bibliographic Details
Main Authors: Wanlin eYang, Aijuan eYan, Tingting eZhang, Jiaxiang eShao, Tengyuan eLiu, Xiao eyang, Weiliang eXia, Yi eFu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
Inflammation
Microglia
ERK
cerebral ischemia
Thromboxane A2 receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00008/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00008/full

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