On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy

The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA...

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Bibliographic Details
Main Authors: Santiago Gómez-Ruiz, Danijela Maksimović-Ivanić, Sanja Mijatović, Goran N. Kaluđerović
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2012/140284