Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells

Nicotinamide <i>N</i>-methyltransferase (NNMT) plays multiple roles in improving the aggressiveness of colorectal cancer (CRC) and enhancing resistance to 5-Fluorouracil (5-FU), making it an attractive therapeutic target. Curcumin (Cur) is a promising natural compound, exhibiting multipl...

Full description

Bibliographic Details
Main Authors: Guoli Li, Sining Fang, Xiao Shao, Yejia Li, Qingchao Tong, Beibei Kong, Lifen Chen, Yanzhong Wang, Jun Yang, Haitao Yu, Xinyou Xie, Jun Zhang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
nicotinamide <i>N</i>-methyltransferase
chemoresistance
curcumin
cell cycle arrest
colorectal cancer
Online Access:https://www.mdpi.com/2218-273X/11/9/1295

Internet

https://www.mdpi.com/2218-273X/11/9/1295

Similar Items