Targeting LOX-1 Inhibits Colorectal Cancer Metastasis in an Animal Model

Targeting LOX-1 Inhibits Colorectal Cancer Metastasis in an Animal Model

Recurrence and metastasis are the primary causes of mortality in patients with colorectal cancer (CRC), and therefore effective tools to reduce morbidity and mortality of CRC patients are necessary. LOX-1, the ox-LDL receptor, is strongly involved in inflammation, obesity, and atherosclerosis, and s...

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Bibliographic Details
Main Authors: Michela Murdocca, Rosamaria Capuano, Sabina Pucci, Rosella Cicconi, Chiara Polidoro, Alexandro Catini, Eugenio Martinelli, Roberto Paolesse, Augusto Orlandi, Ruggiero Mango, Giuseppe Novelli, Corrado Di Natale, Federica Sangiuolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
LOX-1
shRNAs
xenograft model
neo-angiogenesis
metastatic cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00927/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00927/full

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