Interference chromatography: a novel approach to optimizing chromatographic selectivity and separation performance for virus purification

Interference chromatography: a novel approach to optimizing chromatographic selectivity and separation performance for virus purification

Abstract Background Oncolytic viruses are playing an increasingly important role in cancer immunotherapy applications. Given the preclinical and clinical efficacy of these virus-based therapeutics, there is a need for fast, simple, and inexpensive downstream processing methodologies to purify biolog...

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Bibliographic Details
Main Authors: Lisa A. Santry, Renaud Jacquemart, Melissa Vandersluis, Mochao Zhao, Jake M. Domm, Thomas M. McAusland, Xiaojiao Shang, Pierre M. Major, James G. Stout, Sarah K. Wootton
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Biotechnology
Subjects:
Interference chromatography
Anion exchange membrane
Single-use bioprocessing
Oncolytic virotherapy
Newcastle disease virus
Virus purification
Online Access:http://link.springer.com/article/10.1186/s12896-020-00627-w

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http://link.springer.com/article/10.1186/s12896-020-00627-w

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