Potent Anti-Ovarian Cancer with Inhibitor Activities on Both Topoisomerase II and <sup>V600E</sup>BRAF of Synthesized Substituted Estrone Candidates

Potent Anti-Ovarian Cancer with Inhibitor Activities on Both Topoisomerase II and <sup>V600E</sup>BRAF of Synthesized Substituted Estrone Candidates

A series of 16-(&#945;-alkoxyalkane)-17-hydrazino-estra-1(10),2,4-trien[17,16-c]-3-ol (<b>3a</b>&#8722;<b>l</b>) and estra-1(10),2,4-trien-[17,16-c]pyrazoline-3-ol derivatives (<b>4a</b>&#8722;<b>d</b>) were synthesized from corresponding a...

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Bibliographic Details
Main Authors: Mohamed El-Naggar, Abd El-Galil E. Amr, Ahmed A. Fayed, Elsayed A. Elsayed, Mohamed A. Al-Omar, Mohamed M. Abdalla
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
estrone derivatives
hydrazine
N-substituted pyrazoline
anti-ovarian cancer
topoisomerase II inhibitor
kinase inhibitor
Online Access:https://www.mdpi.com/1420-3049/24/11/2054

Internet

https://www.mdpi.com/1420-3049/24/11/2054

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