CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies. Here the authors describe a critical role of CCCTC-binding factor (CTCF)-dependent chromatin reorganization in peripheral myelinat...

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Bibliographic Details
Main Authors: Jincheng Wang, Jiajia Wang, Lijun Yang, Chuntao Zhao, Laiman Natalie Wu, Lingli Xu, Feng Zhang, Qinjie Weng, Michael Wegner, Q. Richard Lu
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17955-2

Internet

https://doi.org/10.1038/s41467-020-17955-2

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