Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides

Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides

The new series of 3-(2-chlorophenyl)- and 3-(3-chlorophenyl)-pyrrolidine-2,5-dione-acetamide derivatives as potential anticonvulsant and analgesic agents was synthesized. The compounds obtained were evaluated in the following acute models of epilepsy: maximal electroshock (MES), psychomotor (6 Hz, 3...

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Bibliographic Details
Main Authors: Małgorzata Góra, Anna Czopek, Anna Rapacz, Anna Gębska, Katarzyna Wójcik-Pszczoła, Elżbieta Pękala, Krzysztof Kamiński
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
anticonvulsant activity
antinociceptive activity
pyrrolidine-2,5-dione
amides
Online Access:https://www.mdpi.com/1420-3049/26/6/1564

Internet

https://www.mdpi.com/1420-3049/26/6/1564

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