S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer’s Disease Features Progression in TgCRND8 Mice

S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer’s Disease Features Progression in TgCRND8 Mice

Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer’s Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We hav...

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Bibliographic Details
Main Authors: Rosaria A. Cavallaro, Vincenzina Nicolia, Maria Teresa Fiorenza, Sigfrido Scarpa, Andrea Fuso
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Antioxidants
Subjects:
Alzheimer’s disease
oxidative stress
S-adenosylmethionine
superoxide dismutase
one-carbon metabolism
Online Access:https://www.mdpi.com/2076-3921/6/4/76

Internet

https://www.mdpi.com/2076-3921/6/4/76

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