Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification

Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification

We examined the roles of phospholipase A2 (PLA2) in oxidized LDL (oxLDL)-induced cholesteryl ester formation in macrophages. In [3H]oleic acid-labeled RAW264.7 cells and mouse peritoneal macrophages, oxLDL induced [3H]cholesteryl oleate formation with an increase in free [3H]oleic acid and a decreas...

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Bibliographic Details
Main Authors: Satoshi Akiba, Yukimasa Yoneda, Satoshi Ohno, Megumi Nemoto, Takashi Sato
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Journal of Lipid Research
Subjects:
cholesteryl ester
cytosolic phospholipase A2
foam cell
hydroxyoctadecadienoic acid
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337305

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http://www.sciencedirect.com/science/article/pii/S0022227520337305

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