In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs

In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs

Background: High-dose, pharmacological ascorbate (P-AscH−) is preferentially cytotoxic to human cancer cells in vitro. Investigations on the efficacy of P-AscH− as an adjuvant treatment for multiple human cancers are on-going, but has yet to be formally investigated in dogs. The primary objectives o...

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Bibliographic Details
Main Authors: Margaret L. Musser, Alyssa L. Mahaffey, Melissa A. Fath, Garry R. Buettner, Brett A. Wagner, Benjamin K. Schneider, Yeon-Jung Seo, Jonathan P. Mochel, Chad M. Johannes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Veterinary Science
Subjects:
canine
vitamin C
high-dose
osteosarcoma
intravenous
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2019.00385/full

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https://www.frontiersin.org/article/10.3389/fvets.2019.00385/full

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