The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

Large Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gamma...

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Main Authors: Kathleen E. Orrell, Michael J. Mansfield, Andrew C. Doxey, Roman A. Melnyk
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14306-z
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spelling doaj-b882a90d75044ebbb51ee0106300e9432021-05-11T08:12:41ZengNature Publishing GroupNature Communications2041-17232020-01-0111111110.1038/s41467-020-14306-zThe C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatusKathleen E. Orrell0Michael J. Mansfield1Andrew C. Doxey2Roman A. Melnyk3Molecular Medicine Program, The Hospital for Sick Children Research InstituteDepartment of Biology, University of WaterlooDepartment of Biology, University of WaterlooMolecular Medicine Program, The Hospital for Sick Children Research InstituteLarge Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gammaproteobacterium Serratia marcescens.https://doi.org/10.1038/s41467-020-14306-z
collection DOAJ
language English
format Article
sources DOAJ
author Kathleen E. Orrell
Michael J. Mansfield
Andrew C. Doxey
Roman A. Melnyk
spellingShingle Kathleen E. Orrell
Michael J. Mansfield
Andrew C. Doxey
Roman A. Melnyk
The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
Nature Communications
author_facet Kathleen E. Orrell
Michael J. Mansfield
Andrew C. Doxey
Roman A. Melnyk
author_sort Kathleen E. Orrell
title The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_short The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_full The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_fullStr The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_full_unstemmed The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_sort c. difficile toxin b membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description Large Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gammaproteobacterium Serratia marcescens.
url https://doi.org/10.1038/s41467-020-14306-z
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