The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

by Kathleen E. Orrell, Michael J. Mansfield, Andrew C. Doxey, Roman A. Melnyk
Published 2020-01-01

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

by John Tam, Therwa Hamza, Bing Ma, Kevin Chen, Greg L. Beilhartz, Jacques Ravel, Hanping Feng, Roman A. Melnyk
Published 2018-12-01

The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.

by Terry W Bilverstone, Megan Garland, Rory J Cave, Michelle L Kelly, Martina Tholen, Donna M Bouley, Philip Kaye, Nigel P Minton, Matthew Bogyo, Sarah A Kuehne, Roman A Melnyk
Published 2020-09-01