CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK). In animals, the only known CAK for CDK2 and CDK1 is cyclin H-CDK7, which is constitutively active. The...

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Bibliographic Details
Main Authors: Xavier Bisteau, Sabine Paternot, Bianca Colleoni, Karin Ecker, Katia Coulonval, Philippe De Groote, Wim Declercq, Ludger Hengst, Pierre P Roger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3667761?pdf=render

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http://europepmc.org/articles/PMC3667761?pdf=render

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