Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment

Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment

<p>Abstract</p> <p>Background</p> <p>Development of compensatory mutations within the HIV p7/p1 and p1/p6 protease cleavage site region has been observed in HIV-infected patients treated with protease inhibitors. Mechanisms of fitness compensation may occur in HCV popul...

Full description

Bibliographic Details
Main Authors: Sullivan James C, Zhang Eileen Z, Bartels Doug J, Tigges Ann, Dorrian Jennifer L, Kwong Ann D, Kieffer Tara L
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Virology Journal
Subjects:
Directional selection
Fitness
INCIVEK
Telaprevir
Online Access:http://www.virologyj.com/content/9/1/147

Internet

http://www.virologyj.com/content/9/1/147

Similar Items