Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

Abstract Background The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immune reactions drives axonal damage and neuron loss in the CNS of palmitoy...

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Bibliographic Details
Main Authors: Kristina Berve, Brian L. West, Rudolf Martini, Janos Groh
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Neuronal ceroid lipofuscinosis
Microglia
Macrophages
T lymphocytes
Neurodegeneration
Axon degeneration
Online Access:http://link.springer.com/article/10.1186/s12974-020-01996-x

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http://link.springer.com/article/10.1186/s12974-020-01996-x

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