Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans.

Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans.

In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nuclear hormone receptor, NHR-49, enables the response to this physiological change by increasing the expression of genes involved in mitochondrial β-oxidation and fatty-acid desaturation. The coordinated...

Full description

Bibliographic Details
Main Authors: Ramesh Ratnappan, Francis R G Amrit, Shaw-Wen Chen, Hasreet Gill, Kyle Holden, Jordan Ward, Keith R Yamamoto, Carissa P Olsen, Arjumand Ghazi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4256272?pdf=render

Internet

http://europepmc.org/articles/PMC4256272?pdf=render

Similar Items