Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner

Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner

Inflammatory bowel diseases (IBDs) are characterized by chronic, inflammatory gastrointestinal lesions and often require life-long treatment with immunosuppressants and repetitive surgical interventions. Despite progress in respect to the characterization of molecular mechanisms e.g. exerted by TNF-...

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Bibliographic Details
Main Authors: Vera Buchele, Patrick Konein, Tina Vogler, Timo Kunert, Karin Enderle, Hanif Khan, Maike Büttner-Herold, Christian H. K. Lehmann, Lukas Amon, Stefan Wirtz, Diana Dudziak, Markus F. Neurath, Clemens Neufert, Kai Hildner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
interferon regulatory factor 4 (IRF4)
myeloid cells
Th17
intestinal inflammation
inflammatory bowel disease (IBD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.590893/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.590893/full

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