Combined Effects of Exercise and Denosumab Treatment on Local Failure in Post-menopausal Osteoporosis–Insights from Bone Remodelling Simulations Accounting for Mineralisation and Damage

Combined Effects of Exercise and Denosumab Treatment on Local Failure in Post-menopausal Osteoporosis–Insights from Bone Remodelling Simulations Accounting for Mineralisation and Damage

Denosumab has been shown to increase bone mineral density (BMD) and reduce the fracture risk in patients with post-menopausal osteoporosis (PMO). Increase in BMD is linked with an increase in bone matrix mineralisation due to suppression of bone remodelling. However, denosumab anti-resorptive action...

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Bibliographic Details
Main Authors: Javier Martínez-Reina, José L. Calvo-Gallego, Peter Pivonka
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
post-menopausal osteoporosis
bone turnover
bone mineralisation
denosumab
PK-PD modelling
bone mineral density
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.635056/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.635056/full

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