Reduced Expression of Hippocampal GluN2A-NMDAR Increases Seizure Susceptibility and Causes Deficits in Contextual Memory

Reduced Expression of Hippocampal GluN2A-NMDAR Increases Seizure Susceptibility and Causes Deficits in Contextual Memory

N-methyl-D-aspartate receptors are heterotetramers composed of two GluN1 obligatory subunits and two regulatory subunits. In cognitive-related brain structures, GluN2A and GluN2B are the most abundant regulatory subunits, and their expression is subjected to tight regulation. During development, Glu...

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Bibliographic Details
Main Authors: Maria Florencia Acutain, Jordana Griebler Luft, Cecila Alejandra Vazquez, Bruno Popik, Magalí C. Cercato, Alberto Epstein, Anna Salvetti, Diana A. Jerusalinsky, Lucas de Oliveira Alvares, Maria Verónica Baez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neuroscience
Subjects:
NMDA receptors
GluN2A subunit
GluN2A/GluN2B
mRNA silencing
long-term memory
seizure induction
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.644100/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.644100/full

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