Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) with mild cognitive impairment. Hyperammonemia is a main contributor to cognitive impairment in MHE, which is mediated by neuroinflammation. GABAergic neurotransmission is altered in hyperammonemic rats. We hypothesized t...

Full description

Bibliographic Details
Main Authors: Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felipo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
hepatic encephalopathy
GABAA receptor
hippocampus
spatial learning and memory
anxiety
glutamate receptors
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00132/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00132/full

Similar Items