Circumventing the side effects of L-asparaginase

Circumventing the side effects of L-asparaginase

L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblastic leukemia. L-asparaginase toxicity is either related to hypersensitivity to the foreign protein or to a secondary L-glutaminase activity that causes inhibition of pro...

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Bibliographic Details
Main Authors: Marcela Helena Gambim Fonseca, Tayná da Silva Fiúza, Stephanie Bath de Morais, Tatiana de Arruda Campos Brasil de Souza, Raphael Trevizani
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Immunogenicity
L-glutaminase activity
Half-life
Epitope prediction
Deimmunization
Protein engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004017

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221004017

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