Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients

Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients

The fetal hemoglobin (HbF) levels and ßS-globin gene haplotypes of 125 sickle cell anemia patients from Brazil were investigated. We sequenced the Gg- and Ag-globin gene promoters and the DNase I-2 hypersensitive sites in the locus control regions (HS2-LCR) of patients with HbF level disparities as...

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Bibliographic Details
Main Authors: E.V. Adorno, J.P. Moura-Neto, I. Lyra, A. Zanette, L.F.O. Santos, M.O. Seixas, M.G. Reis, M.S. Goncalves
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2008-02-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Fetal hemoglobin
Sickle cell anemia
ßS-globin gene haplotypes
Locus control region
g-globin promoter
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200003

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200003

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