Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4+CD25+T regulatory cells that inhibit allograft rejection in unmodified recipients.

Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4+CD25+T regulatory cells that inhibit allograft rejection in unmodified recipients.

In rat models, CD4+CD25+T regulatory cells (Treg) play a key role in the induction and maintenance of antigen specific transplant tolerance, especially in DA rats with PVG cardiac allografts(1, 2). We have previously described generation of alloantigen specific Treg (Ts1), by culture of naïve natur...

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Bibliographic Details
Main Authors: Nirupama Darshan Verma, Bruce Milne Hall, Karren Michelle Plain, Catherine M. Robinson, Rochelle eBoyd, Giang eTran, Chuanmin eWang, G. Alex eBishop, Suzanne J. Hodgkinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
T regulatory cells
allograft rejection
IL-12p70
antigen specific Treg
Th1 like Treg
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00190/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00190/full

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