Methylated HBHA produced in M. smegmatis discriminates between active and non-active tuberculosis disease among RD1-responders.

BACKGROUND: A challenge in tuberculosis (TB) research is to develop a new immunological test that can help distinguish, among subjects responsive to QuantiFERON TB Gold In tube (QFT-IT), those who are able to control Mtb replication (remote LTBI, recent infection and past TB) from those who cannot (...

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Main Authors: Giovanni Delogu, Teresa Chiacchio, Valentina Vanini, Ornella Butera, Gilda Cuzzi, Alessandra Bua, Paola Molicotti, Stefania Zanetti, Francesco Nicola Lauria, Susanna Grisetti, Nicola Magnavita, Giovanni Fadda, Enrico Girardi, Delia Goletti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3066236?pdf=render