Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Background: The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist, may reduce alcohol consumption, craving and promote abstinence. However, the optimal dose to treat alcohol dependence is...

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Bibliographic Details
Main Authors: Claire F. Durant, Louise M. Paterson, Sam Turton, Susan J. Wilson, James F. M. Myers, Suresh Muthukumaraswamy, Ashwin Venkataraman, Inge Mick, Susan Paterson, Tessa Jones, Limon K. Nahar, Rosa E. Cordero, David J. Nutt, Anne Lingford-Hughes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Psychiatry
Subjects:
baclofen (PubChem CID: 2284)
addiction
pharmacodynamic (PD)
pharmacokinetic (PK)
alcohol use disorder (AUD)
GABA-B receptor
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00664/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2018.00664/full

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