Bi-directional effect of increasing doses of baclofen on reinforcement learning

Bi-directional effect of increasing doses of baclofen on reinforcement learning

In rodents as well as in humans, efficient reinforcement learning depends on dopamine (DA) released from ventral tegmental area (VTA) neurons. It has been shown that in brain slices of mice, GABAB-receptor agonists at low concentrations increase the firing frequency of VTA-DA neurons, while high con...

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Bibliographic Details
Main Authors: Jean eTerrier, Andres eOrt, Cédric eYvon, Arnaud eSaj, Patrik eVuilleumier, Christian eLüscher
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Baclofen
Ventral Tegmental Area
mesolimbic dopamine system
anti-craving treatment
bi‐directional effect
instrumental learning
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00040/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00040/full

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